Thanks for the replies! I guess the post title should have been "Sammich problems with VISTA 64"
I think I have tried all the combinations of connections in the editor, I thought the same thing since MIOS Studio was working the Editor should too, but no luck.
I even tried switching the physical MIDI ports on the 2X2. I had no problems setting it up on 2 different XP 32-bit machines so it HAS to be something to do with VISTA.
Yes it is the 2X2 anniversary edition and all drivers and firmware are up to date.
I will check the thread mentioned above and see if it helps. If not I might have to install XP on my laptop...if anyone else thinks of anything I could try let me know.
Thanks again guys, if I do figure it out I'll post the solution here.
Regards,
Claiborne