Thank you for the answers! 
Nothing extreme happened with the pic, but i tried it with an other one, and experienced the same. 
The SRIO interconnection test application changes the voltage on PIN21, so PIC error can be excluded I think. 
Sorry for the stupid questions, I'm very new to Midibox. 
So: there is one PIC based core, tried with one DINX4 module. 
Bootloader, MIOS V1.9g and setup_midio128.hex uploaded. (ini to syx conversion still not done) 
Nothing happens on grounding DIN inputs (and cannot detect CLK signal on PIN21) 
What to do now??? 
  
Best regards 
Csaba