Thanks for the tip, but no, doesn't seem to be them, they are fairly cool. I'm using the optimized C64 PSU design, and the power is stable and voltage high enough (also over IC socket). And actually, it doesn't start at all now. A selection of leds light up, top line of display is shaded (but not black). I have tried disconnecting DINs and DOUTs, uploading the application without control surface enabled, so it's not the serial registers. When uploading, confirm messages were returned via midi, so the PIC is alive, so is the optocoupler, even tried replacing with a new PIC. Today i'll try replacing the EEPROM. Thorsten, what elements are actually initialized, ie. where the PIC relies on a response, at startup?