Certain games like Another World, Tales Of Phantasia, Star Ocean use streamed music or SFX in game. For example, Tales Of Phantasia use streaming and sequenced music at the same time (in introduction, music is sequenced and lyrics is streamed from the cartidge). In conclusion, it is possible to play arbitrary note. Moreover, the sound effect in game is in real time and when the SFx is too big for SPC's memory, it read from cartidge.