Lemme first answer to clem's answers ;) I am sure he means CV, as that's what he explicitly asked for MIDI-to-CV (midiboxCV) ;) That's the thing. A modular synthesizer doesn't really have a protocol. It has knobs and it has patch cables. ...with the right software ;) Correct, tricky... but doable. Well kinda. You can obviously not [with decent effort] control all the tuning trim pots in a VCO, but you could "adjust" the "finetune pot". Astronom: What you are describing here is a very, very complex idea. To save patches of a big modular system (16 VCOs is a pretty fargin big one) you'd need a very elaborate system. It would need a gigantic digitally controlled routing matrix (virtual cables), to save "presets". So the simple answer is: While technically/hypothetically possible, no, you can't really control the entire modular and save patches, unless you are very very good with electronics and have a lot, and I do mean a lot, of disposable cash. I think you should dive in and read up on modulars a bit more, that should answer most of your questions.